Vive la différence!

When your write for the masses, people are going to have something to say about it. This is unavoidable.

(cleansing breath)

For a writer it will be a blessing and a curse.  Not "can be"...WILL be.  Some people will get exactly what you're trying to say—others will miss the point by a country mile.  One person will say the use of the [insert noun] as a metaphor for the main character's [insert plight] was brilliant.  Another person will say it confused them or it had no place in the story. 

(sigh)

I have a narrow strip of paper taped to the side of my computer monitor.  It says "Unicorns and Rainbows...Vampires and Werewolves."  It's there to remind me that different people like different things.  The reviewer who loves baby unicorns probably won't understand your story about the cute blonde math teacher turned vampire.  Sing it with me..."You say "tomato"...I say  "to-mah-to..."  

It's the human condition, so my advice to you—get used to it.  Spock was right when he said "humans are illogical."  We are...for the lack of a better term...only human.  As a writer you need to adopt a Vulcan mindset.  Yes, you DO need to be mindful of where you send your work, who is reading it, and so on.  As mentioned previously, make sure it's going to the publisher/agent/reviewer who is looking for werewolf stories, or historical romance, or books about moose that talk.  And be like Spock.

Live long and prosper.